- Original Article
- Immunohistochemical Expression of c-fos Protein and Histologic Findings after Instillation of Kainic Acid in Hippocampus of Neonatal Rat Brain
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Soo Ahn Chae, Yong Soo Kim, Byoung Hoon Yoo, Won Bok Lee
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Clin Exp Pediatr. 1999;42(4):553-560. Published online April 15, 1999
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Purpose : c-fos is rapidly and transiently induced in the intact CNS by a wide variety of exogenous stimuli that include seizures, glutamate receptor activation, sensory stimulation and stress. In adult animals, systemic KA administration produces limbic seizures that results in c-fos protein expression, irreversible morphological changes and localized neuronal death. So we studied the pattern of c-fos protein expression... |
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